Unità di Ricerca: Genetica Molecolare del Cancro

Unità di Ricerca: Genetica Molecolare del Cancro
Responsabile: Prof. Giuseppe Giannini


Principali linee di ricerca

  •  Genetica molecolare delle neoplasie della mammella, ovaio e colon-retto. Test genetici BRCA1, BRCA2 e APC
  •  La risposta al danno del DNA nello sviluppo e nella carcinogenesi neuronale. 
  •  Molecole e pathways della carcinogenesi neuroectodermica: MYCN in neuroblastoma e medulloblastoma.

 

Progetti di ricerca finanziati  (anni 2010-2012)

Responsabile scientifico:  Giuseppe Giannini
2011. "Understanding the molecular functions of Myc proteins at the border between proliferation and apoptosis: implications for new therapies”. Ricerche Universitarie ‘Sapienza’Università di Roma. Euro 27.500.
2011-2014. "Crosstalk between the DNA Damage Response pathway and MYCN in neuronal development and carcinogenesis”. AIRC Investigator Grant.Euro 80.000.
2012. “The DNA Damage Response (DDR) as a potential therapeutic target for MYCN-dependent tumors”. Ricerche Universitarie ‘Sapienza’Università di Roma. Euro 40.000.


Pubblicazioni più rilevanti (anni 2010-2012).

Veschi V, Petroni M, Cardinali B, Dominici C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Giannini G. Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells. PLoS One.2012; 7(11):e49139. Epub 2012 Nov 9.

Petroni M, Veschi V, Gulino A, Giannini G. Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille's heel to be exploited for the therapy of MYCN-amplified neuroblastoma. Front Oncol. 2012; 2:141.

Orr N, Lemnrau A, Cooke R, Fletcher O, Tomczyk K, Jones M, Johnson N, Lord CJ, Mitsopoulos C, Zvelebil M, McDade SS, Buck G, Blancher C; KConFab Consortium, Trainer AH, James PA, Bojesen SE, Bokmand S, Nevanlinna H, Mattson J, Friedman E, Laitman Y, Palli D, Masala G, Zanna I, Ottini L, Giannini G, Hollestelle A, Ouweland AM, Novaković S, Krajc M, Gago-Dominguez M, Castelao JE, Olsson H, Hedenfalk I, Easton DF, Pharoah PD, Dunning AM, Bishop DT, Neuhausen SL, Steele L, Houlston RS, Garcia-Closas M, Ashworth A, Swerdlow AJ. Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nat Genet. 2012 Sep 23;44(11):1182-4.

Ottini L, Silvestri V, Rizzolo P, Falchetti M, Zanna I, Saieva C, Masala G, Bianchi S, Manoukian S, Barile M, Peterlongo P, Varesco L, Tommasi S, Russo A, Giannini G, Cortesi L, Viel A, Montagna M, Radice P, Palli D. Clinical and pathologic characteristics of BRCA-positive and BRCA-negative male breast cancer patients: results from a collaborative multicenter study in Italy. Breast Cancer Res Treat. 2012 Jul;134(1):411-8. Epub 2012 Apr 18.

Massimi I, Guerrieri F, Petroni M, Veschi V, Truffa S, Screpanti I, Frati L, Levrero M, Gulino A, Giannini G. The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1. Mol Carcinog. 2012 Mar 2. [Epub ahead of print]

Antoniou AC, Kartsonaki C, Giannini G, Easton DF, Chenevix-Trench G; on behalf of CIMBA. Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carrier. Hum Mol Genet. 2011 Aug 15;20(16):3304-21.

Petroni M, Veschi V, Prodosmo A, Rinaldo C, Massimi I, Carbonari M, Dominici C, McDowell HP, Rinaldi C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Soddu S, Giannini G. MYCN Sensitizes Human Neuroblastoma to Apoptosis by HIPK2 Activation through a DNA Damage Response. Mol Cancer Res. 2011 Jan;9(1):67-77.

Zanna I, Rizzolo P, Sera F, Falchetti M, Aretini P, Giannini G, Masala G, Gulino A, Palli D, Ottini L. The BRCAPRO 5.0 model is a useful tool in genetic counseling and clinical management of male breast cancer cases. Eur J Hum Genet. 2010 Jul;18(7):856-8.

Silvestri V, Rizzolo P, Zanna I, Falchetti M, Masala G, Bianchi S, Papi L, Giannini G, Palli D, Ottini L. PALB2 mutations in male breast cancer: a population-based study in Central Italy. Breast Cancer Res Treat. 2010 Jul;122(1):299-301.

Forloni M, Albini S, Limongi MZ, Cifaldi L, Boldrini R, Nicotra MR, Giannini G, Natali PG, Giacomini P, Fruci D. NF-kappaB, and not MYCN, Regulates MHC Class I and Endoplasmic Reticulum Aminopeptidases in Human Neuroblastoma Cells. Cancer Res. 2010 Feb 1;70(3):916-24.